منابع مشابه
69 Severe Cutaneus Drug Reactions: Description of a Serie Cases
medications in the world. Our objective was to estimate the severity and incidence of adverse reactions to MC, first administered in hospitalized patients. Methods: We prospectively studied 99 patients requiring computed tomography (CT) enhanced with MC. Immediate adverse reactions were identified by direct questioning and/or physical examination after administration of iodinated CM nonionic lo...
متن کاملAnticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study
Background: Severe Adverse Cutaneous Reactions to Drugs (SACRDs) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients. Objectives: The aim of this study was to determine the offending drug/agents and clinical phenotypes of SACRDs leading to admissions to the hospital. Materials & Methods: We conducted a retrospective cross-sectional study during one year (March...
متن کامل[Predictive genomic markers for severe adverse drug reactions].
Severe adverse drug reactions are an important issue to be considered during proper drug usage in postmarketing period. Most severe adverse reactions are idiosyncratic and unrelated to their pharmacological actions via primary targets. Although these reactions were not predictable, recent developments in the field of genomics have revealed closely associated markers responsible for some severe ...
متن کاملImmunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Est...
متن کاملSevere drug-induced skin reactions: clinical pattern, diagnostics and therapy.
The spectrum of severe drug-induced skin reactions includes not only Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) but also generalized bullous fixed drug eruption (GBFDE), acute generalized exanthematous pustulosis (AGEP) and hypersensitivity syndrome (HSS), also called drug reaction with eosinophilia and systemic symptoms (DRESS). These reactions differ in clinical prese...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2012
ISSN: 1939-4551
DOI: 10.1097/01.wox.0000411814.65700.d6